Health Economics &
Real-World Evidence Solutions

Utilizing our extensive experience in gathering data from diverse sources to improve healthcare decisions

SIRO integrates rigorous systematic review, real-world evidence, and health economic expertise to support HTA submissions, market access strategies, and publication programmes.

Differentiators

Expertise in Real-World Data Collection and Analysis

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Connects with investigators and engagements with hospitals help us generate prospective real-world data and accessing healthcare data for retrospective analysis

Specialised writers

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Dedicated writers for real world evidence and outcomes research publications expertise in value communications

Competence exhibition at global platforms

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Regular presentations at ISMPP/ISPOR, webinars and workshops

Analysts specially trained to cater different needs

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Analysts with public health and epidemiology background trained on regression analysis, survival analysis, meta-analysis and pharmacoeconomic modelling

Delivering Cutting-Edge Solutions and Services Across all HEOR Domains

Evidence Generation

  • Systematic Literature Reviews (SLR)
  • Targeted Literature Reviews (TLR)
  • Rapid reviews for time-sensitive evidence needs
  • Living reviews for update-ready evidence generation
  • Structured search strategy development aligned to PRISMA principles

SLR / TLR Deep Dive

End-to-end systematic review, built for HTA and beyond

Each SLR or TLR is designed to serve multiple downstream purposes - from NMA inputs to publication manuscripts to payer evidence packages.

Protocol & Search Design
PICOS-guided protocol development with pre-registration on PROSPERO. Boolean logic search strings across MEDLINE, Embase, CENTRAL, and grey literature sources.
Dual Screening & Extraction
Independent dual-reviewer screening at title/abstract and full-text stages. Structured data extraction and risk of bias assessment using RoB 2.0, ROBINS-I, and NOS.
Quantitative Synthesis & NMA
Meta-analysis, indirect treatment comparisons, and network meta-analysis using frequentist and Bayesian approaches. Full heterogeneity and consistency assessments.
PRISMA Reporting Manuscripts
Full PRISMA-compliant SLR reports and publication-ready manuscripts. Writers experienced in peer-reviewed submissions and conference posters at ISPOR, Cochrane, and HTAi.

SLR / TLR lifecycle

A structured, transparent process from protocol registration to final deliverable - with your team at every checkpoint.

1

Scope & Protocol

PICOS, PROSPERO, search sources agreed

2

Literature Search

Multi-database + grey literature

3

Dual Screening

Title/abstract → full-text, PRISMA flow

4

Extraction & QA

Structured data, RoB / NOS assessment

5

Synthesis

Narrative, meta-analysis, or NMA

6

Outputs

Report, manuscript, HTA / payer pack

AI-Enabled, Human-led Workflows

SIRO uses AI to improve search efficiency, deduplication, initial screening assist, and output structuring - every step remains human-validated and quality-controlled by HEOR specialists. This ensures reproducibility and compliance with HTA and regulatory standards.

Case Studies
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As a part of market access strategy, client wanted to defend their product pipeline for a particular disease area

Effectively communicate information to external stakeholders, read more

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Client was facing challenges related to the market access of their pain management portfolio

Client wanted to identify physicians'/patients' perceptions, read more

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Pharma giant wanted to launch their new Drug to 9 different countries of Asia-Pacific market

Their global market access team wanted to decide market access read more

Learn More